Las Vegas Boulevard is the current name for Route 604 in the city of Las Vegas. This section of road has had several names, including: 5th Street, the Arrowhead Highway, Los Angeles Highway, Salt Lake Highway, U.S. Highway 91 (entire segment), U.S. Highway 93 (from Fremont Street north), U.S. Highway 466 (from Jean to Fremont Street, including the Las Vegas Strip) and Nevada State Route 6 (entire segment, not signed).

With the construction of I-15, Las Vegas Boulevard went from being the main through road to one that only served as a bypass for travelers. The name change reflects its local importance rather than past names when it served as a main intra city road.

Las Vegas Boulevard, while running the length of the city of Las Vegas, Nevada is located mostly in Clark County, Nevada. "The Boulevard", as it is sometimes called by longtime Las Vegas residents, starts at Apex, Nevada and continues south to about 2 miles south of Jean, Nevada.

At its northern end in Apex, the Boulevard starts in an industrial complex of manufacturing plants and power plants running along the Union Pacific Railroad line. As you travel south, the road meets Nellis Air Force Base on the east side and the Las Vegas Motor Speedway on the west side.

As the road enters North Las Vegas, it passes through some of the older commercial areas of the area. As the road approaches Las Vegas itself, you see some of what Vegas was as some of the older casinos appear along with some of the older and more famous strip clubs.

On entering the city of Las Vegas, the Boulevard showcases the city's past with a number of museums. the Old Las Vegas Mormon State Historic Park and the Neon Museum at the Fremont Street Experience. On crossing Washington Street, the Boulevard is designated as the Downtown Las Vegas Boulevard Scenic Byway by the state. This designation continues down to Sahara Avenue.

Further south is a stretch of road that has many of the older motels, bars and wedding chapels that were among the high points of the old Vegas before the era of the megaresorts.